Improvement of liver function parameters in advanced HCV-associated liver cirrhosis by IFN-free antiviral therapies
نویسندگان
چکیده
منابع مشابه
Management of HCV-Associated Liver Cirrhosis.
BACKGROUND Treatment of chronic hepatitis C infection is most urgent in patients with severe liver fibrosis and cirrhosis because of the high risk of decompensation, hepatocellular carcinoma, and consecutively death. The development and approval of several direct-acting antiviral drugs (DAA) in the past years has revolutionized antiviral therapy especially for patients with liver cirrhosis. M...
متن کاملHepatic myelopathy associated with advanced liver cirrhosis.
A 41-year-old man was admitted to our institution with inertia of both lower extremities and walking instability. The patient had been diagnosed with chronic hepatitis B (hepa B) for 10 years, including hepa B virus associated cirrhosis within the last 4 years. The patient had also suffered hepatic encephalopathy within the last 6 months, which resolved following treatment. A month before the c...
متن کاملAn interferon-free antiviral regimen for HCV after liver transplantation.
BACKGROUND Hepatitis C virus (HCV) infection is the leading indication for liver transplantation worldwide, and interferon-containing regimens are associated with low response rates owing to treatment-limiting toxic effects in immunosuppressed liver-transplant recipients. We evaluated the interferon-free regimen of the NS5A inhibitor ombitasvir coformulated with the ritonavir-boosted protease i...
متن کاملSevere inflammation in the background liver cirrhosis correlates with the development of poorly differentiated HCC in HCV-associated liver cirrhosis.
OBJECTIVE Whether severe inflammation in the background liver cirrhosis might correlate with the development of poorly differentiated human hepatocellular carcinoma (HCC) was studied in hepatitis C virus (HCV)-associated liver cirrhosis. METHODS Out of 214 HCC patients who underwent curative hepatic resection, 148 patients were HCV-associated liver cirrhosis (LC) patients. Out of these 148, 3...
متن کاملResponse to standard of care antiviral treatment in patients with HCV liver cirrhosis - a systematic review.
BACKGROUND Patients with HCV liver cirrhosis are a category difficult to treat. The aim of this study was to establish the sustained virological response (SVR) rates in HCV patients with liver cirrhosis treated with standard of care therapy (Pegylated Interferon and Ribavirin for 48 weeks in genotypes 1 and 4 and 24 weeks in genotypes 2 and 3). METHODS Searching the PubMed, Medline, Lilacs, S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2015
ISSN: 0269-2813
DOI: 10.1111/apt.13343